Holiday Inn Conference Center Lehigh Valley hotel is located just five miles from downtown Allentown. The hotel is at the intersection of I 78 and Route 100 South, 12 miles from Lehigh Valley International Airport. From I 78, take exit 49A (Route 100 South). Once you are on 100 South, proceed to the first traffic light.Penn Drive. Turn right onto Penn Drive. Take the first right onto Sycamore and follow to the stop sign. Bear left and the Holiday Inn is straight ahead.